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5-Amino-1MQ
5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) studied in controlled laboratory environments. Researchers use this compound to investigate NNMT activity and its relationship to nicotinamide metabolism, NAD⁺ salvage pathways, and metabolic signaling.
- Small-molecule NNMT inhibitor
- Studied in research involving nicotinamide metabolism and NAD⁺-related pathways
- Used in adipose, metabolic, and cellular research models
- Supplied as a purified lyophilized powder for controlled laboratory research
Save up to 15% when you buy more!
| Quantity | Discount | Price |
|---|---|---|
| 1 | 0% | $75.00 |
| 2 - 5 | 5% | $71.25 |
| 6 - 10 | 10% | $67.50 |
| 11 - 15 | 15% | $63.75 |
Product Specifications
Molecular Formula:
C₁₀H₁₁N₂⁺
Molecular Weight:
~159.21 g/mol
PubChem CID:
950107
CAS Number:
42464-96-0
Vial Size:
3 mL
Contents:
Lyophilized powder, white/off-white color
Mechanism of action
NNMT Enzyme Inhibition
5-Amino-1MQ acts as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that normally uses S-adenosylmethionine (SAM) to methylate nicotinamide and produce 1-methylnicotinamide (1-MNA). By inhibiting NNMT, 5-Amino-1MQ reduces formation of 1-MNA and alters the way nicotinamide and methyl-donor resources are used within the cell. This enzyme-level activity makes 5-Amino-1MQ useful for studying NNMT-dependent metabolic pathways.
NAD⁺ Salvage and SAM Availability
NNMT inhibition can preserve nicotinamide for use in the NAD⁺ salvage pathway while reducing consumption of SAM during nicotinamide methylation. In cultured adipocytes, 5-Amino-1MQ treatment has been associated with increased intracellular NAD⁺ and SAM concentrations alongside reduced 1-MNA. These findings make the compound useful for studying the relationship between NNMT activity, NAD⁺ metabolism, and cellular methyl-donor balance.
Adipocyte Metabolism and Lipogenesis
Preclinical research has also examined how NNMT inhibition affects adipocyte metabolism. In cultured adipocytes, 5-Amino-1MQ was associated with reduced lipogenesis, while animal studies of NNMT inhibition reported changes in adipose mass and adipocyte size. 5-Amino-1MQ is therefore used in research models examining the relationship between NNMT activity, NAD⁺ and SAM metabolism, lipid storage, and broader metabolic regulation. These findings remain preclinical and do not establish corresponding metabolic effects in humans.
Storage & handling
Storage:
Store the lyophilized vial in a cool, dry area protected from direct sunlight.
Certificate of Analysis
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In lyophilized (powder) form, store in freezer for up to 2 years. In reconstituted form, store in fridge and use in 4-8 weeks.
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