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NAD+
$160.00
NAD⁺ (oxidized nicotinamide adenine dinucleotide) is a ubiquitous pyridine nucleotide coenzyme that accepts hydride ions in key metabolic pathways—glycolysis, the tricarboxylic acid cycle, and fatty-acid β-oxidation—to generate NADH for ATP production via oxidative phosphorylation. Beyond its redox role, NAD⁺ serves as an essential cosubstrate for NAD⁺-consuming enzymes such as sirtuin deacetylases and poly-ADP-ribose polymerases, thereby regulating gene expression, DNA-damage repair, and cellular stress responses. NAD⁺ availability also modulates mitochondrial biogenesis and metabolic homeostasis through SIRT1-PGC-1α signaling and impacts aging-related processes, as cellular NAD⁺ levels decline with age.
Save up to 15% when you buy more!
| Quantity | Discount | Price |
|---|---|---|
| 1 | 0% | $160.00 |
| 2 - 5 | 5% | $152.00 |
| 6 - 10 | 10% | $144.00 |
| 11 - 15 | 15% | $136.00 |
Product details
Chemical Name:
Nicotinamide Adenine Dinucleotide (oxidized form)
Molecular Formula:
C₂₁H₂₇N₇O₁₄P₂
Molecular Weight:
663.43 g/mol
PubChem CID:
5883
CAS Number:
53-84-9
Synonyms:
NAD⁺, Coenzyme I
Vial Size:
10 mL
Contents:
Lyophilized powder, white/off-white color
Mechanism of action
Redox Coenzyme in Bioenergetics
NAD⁺ accepts hydride ions from key metabolic pathways—glycolysis, the tricarboxylic acid (TCA) cycle, and fatty‐acid β-oxidation—to form NADH, which then donates electrons to the mitochondrial electron‐transport chain for ATP synthesis via oxidative phosphorylation
Substrate for NAD⁺-Consuming Enzymes
Serves as an obligatory co-substrate for sirtuin deacetylases (e.g., SIRT1/3), poly-ADP-ribose polymerases (PARPs), and the NADase CD38, thereby regulating protein deacetylation, DNA-damage–response ADP-ribosylation, and calcium signaling.
Modulation of Gene Expression & Stress Responses
Through SIRT1-mediated deacetylation of transcriptional regulators (e.g., PGC-1α) and PARP-driven DNA repair, NAD⁺ levels fine-tune mitochondrial biogenesis, antioxidant defenses, and genomic stability under stress conditions.
Salvage Pathway & Mitochondrial Health
The NAMPT-dependent salvage pathway recycles nicotinamide into NAD⁺, sustaining intracellular pools; conversely, age-associated CD38 upregulation degrades NAD⁺, contributing to mitochondrial dysfunction.
Storage & handling
Storage:
Store the lyophilized vial in a cool, dry area protected from direct sunlight.
Certificate of Analysis
99%+ Purity
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Yes! Every product goes through multiple 3rd-party tests to verify purity, accurate weight, and that it’s toxin-free. Each test result is documented in a Certificate of Analysis (COA), which you can download directly from each product page or from our centralized COA library.
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We’re here to guide and support. Please reach out to hello@honestpeptide.com and we’ll respond within 1 business day.
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Your order will be processed in 1–2 business days from the East Cost and shipped with UPS or FedEx Ground (2-5 business days). At this time, we only ship to the United States.
How should I store my peptides?
In lyophilized (powder) form, store in freezer for up to 2 years. In reconstituted form, store in fridge and use in 4-8 weeks.
What is your refund policy?
We are serious about customer satisfaction. If you are not happy with your order, please reach out within 30 days and we will replace or refund your order**.**
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