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TB-500

$90.00

TB-500 (TB500 or Thymosin β-4 Active Fragment) is a synthetic heptapeptide corresponding to the N-terminal actin-binding domain of endogenous Thymosin β-4. It modulates cytoskeletal dynamics by sequestering G-actin monomers and promoting localized F-actin polymerization, thereby enhancing cellular motility and migration. TB-500 upregulates angiogenic growth factors (e.g., VEGF, FGF-2) via MAPK/ERK and PI3K/Akt signaling, driving neovascularization in ischemic or injured tissues. Concurrently, it attenuates pro-inflammatory cytokines (TNF-α, IL-6) through NF-κB inhibition, creating a reparative microenvironment. In in vitro and rodent models, these combined actions support accelerated tissue regeneration, angiogenesis, and reduced inflammatory damage.

Save up to 15% when you buy more!

QuantityDiscountPrice
10%$90.00
2 - 55%$85.50
6 - 1010%$81.00
11 - 1515%$76.50

Product details

Amino Acid Sequence

Ac-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ)

Molecular Formula

C₃₈H₆₈N₁₀O₁₄

Molecular Weight

889.02 g/mol

PubChem CID

62707662

CAS Number

885340-08-9

Vial Size

3ml

Contents

Lyophilized powder, white/off-white color

Mechanism of action

Actin Sequestration & Polymerization Regulation

TB-500 binds G-actin monomers, modulating actin filament dynamics and promoting cytoskeletal reorganization for enhanced cell motility.

Angiogenic Signaling

Upregulates VEGF and FGF-2 expression in endothelial cells, driving angiogenesis and neovascularization in ischemic or injured tissues.

Anti-Inflammatory Cytokine Modulation

Downregulates pro-inflammatory cytokines (e.g., TNF-α, IL-6) and upregulates anti-inflammatory mediators, creating a favorable environment for repair.  

PI3K/Akt & MAPK/ERK Pathway Activation

Stimulates fibroblast and endothelial cell proliferation and migration via key growth-factor signaling cascades.  

Storage & handling

Storage:

Store the lyophilized vial in a cool, dry area protected from direct sunlight.

TB-500

Certificate of Analysis

99%+ Purity
Guaranteed

30-day return policy

Rigorous

Testing

Always 3rd party tested

Fast & Free

Shipping

Sent same day
Free over $150

Customer

Service

24/7 Chat & Email

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FAQs

Why Honest Peptide?
  1. Rigorous Testing, No Exceptions:
 Every batch is 3rd-party tested for purity, weight, and toxins—so you can shop with total confidence.
  2. Priced Right:
 As a family business, we keep costs low and pass the savings directly to you.
  3. Here for You: Fast shipping and real human support, every single time.
Do you test your products and provide COAs?

Yes! Every product goes through multiple 3rd-party tests to verify purity, accurate weight, and that it’s toxin-free. Each test result is documented in a Certificate of Analysis (COA), which you can download directly from each product page or from our centralized COA library.

What if I have more questions?

We’re here to guide and support. Please reach out to hello@honestpeptide.com and we’ll respond within 1 business day.

What is your shipping policy?

Your order will be processed  in 1–2 business days from the East Cost and shipped with UPS or FedEx Ground (2-5 business days). At this time, we only ship to the United States.

How should I store my peptides?

In lyophilized (powder) form, store in freezer for up to 2 years. In reconstituted form, store in fridge and use in 4-8 weeks.

What is your refund policy?

We are serious about customer satisfaction. If you are not happy with your order, please reach out within 30 days and we will replace or refund your order**.**

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