CJC-1295(No Dac)/Ipamorelin

CJC-1295 (No DAC) + Ipamorelin is a dual growth-hormone secretagogue research blend supplied as a high-purity lyophilized powder. It combines CJC-1295 No DAC, also known as Modified GRF (1-29), with Ipamorelin, a selective growth-hormone secretagogue receptor agonist. Together, CJC-1295 (No DAC) and Ipamorelin are studied as a dual-pathway GH secretagogue model: CJC-1295 (No DAC) activates the GHRH receptor pathway, while Ipamorelin activates the ghrelin/GHSR pathway. This makes the blend useful for research into pituitary GH release, pulse dynamics, receptor-specific signaling, and downstream GH/IGF-1 axis activity.

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Product details

Amino Acid Sequence

CJC-1295 (No DAC): H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ Ipamorelin: Aib-His-D-2-Nal-D-Phe-Lys-NH₂

Molecular Formula:

CJC-1295 (No DAC): C₁₅₂H₂₅₂N₄₄O₄₂ Ipamorelin: C₃₈H₄₉N₉O₅

Molecular Weight:

CJC-1295 (No DAC):~3,367.9 g/mol Ipamorelin: ~711.9 g/mol

PubChem CID:

CJC-1295 (No DAC): 91976842 Ipamorelin: 9831659

CAS Number:

CJC-1295 (No DAC):863288-34-0 Ipamorelin: 170851-70-4

Vial Size:

3 mL

Contents:

Lyophilized powder, white/off-white color

Mechanism of action

Dual GH Secretagogue Pathway

CJC-1295 (No DAC) + Ipamorelin is studied as a dual-pathway growth hormone secretagogue blend. CJC-1295 (No DAC) acts through the GHRH receptor pathway, while Ipamorelin acts through the ghrelin / growth-hormone secretagogue receptor pathway. This allows researchers to examine complementary upstream signals involved in endogenous GH release.

GHRH Receptor Agonism

CJC-1295 (No DAC) selectively activates the GHRH receptor on pituitary somatotroph cells. GHRHR activation stimulates adenylate cyclase and the cAMP/PKA signaling cascade, supporting growth hormone release in GH-axis research models. Because the No DAC form lacks the drug-affinity-complex albumin-binding extension, it has a shorter-acting profile than DAC-modified CJC-1295. This makes it useful for models focused on transient, pulse-like GHRH receptor stimulation.

Downstream GH / IGF-1 Signaling

Growth hormone released from the pituitary can stimulate hepatic and peripheral IGF-1 production, allowing researchers to study downstream anabolic, lipolytic, and tissue-remodeling pathways associated with the GH/IGF-1 axis. The blend is therefore relevant to research models examining upstream receptor activation, pituitary GH release, GH pulse dynamics, and downstream IGF-1 pathway activity.

Storage & handling

Storage:

Store the lyophilized vial in a cool, dry area protected from direct sunlight.

CJC-1295(No Dac)/Ipamorelin

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In lyophilized (powder) form, store in freezer for up to 2 years. In reconstituted form, store in fridge and use in 4-8 weeks.

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